SANTA CLARA -- Nose tackle Isaac Sopoaga, who returned to limited practice this week, remains questionable for the 49ers' game Sunday against the Buffalo Bills.
Sopoaga missed last week's game with left knee and ankle sprains sustained late in the Sept. 23 game against Minnesota. The 49ers figure to be in their nickel defense most of the time Sunday against the Bills. Sopoaga is replaced when the 49ers go with five defensive backs, so he probably would not see much playing time anyway.
Cornerback Carlos Rogers (ankle) and running back Brandon Jacobs (knee) are also officially listed as questionable, but both should be available.RELATED: 49ers ket matchup No. 3: Aldon Smith vs. Chris Hairston
Rogers had limited participation in practice all week, while Jacobs made it through his first full week of work. Jacobs missed the first four games of the season. It is unknown how the 49ers plan to use him.Linebacker NaVorro Bowman, who was limited in practice Wednesday and Thursday, returned to full practice on Friday.The Bills will be without two starters on their offensive line: left tackle Cordy Glenn and right guard Kraig Urbik due to ankle injuries. Chad Rinehart, who is slated to replace Urbik, was added to the injury report as questionable with a calf injury.
Questionable RB Brandon Jacobs (knee), CB Carlos Rogers (ankle), NT Isaac Sopoaga (knee, ankle)
Probable: LB NaVorro Bowman (shoulder), P Andy Lee (thumb)BILLS
Out: T Cordy Glenn (ankle), DT Spencer Johnson (ankle), G Kraig Urbik (ankle)
Questionable: S Jairus Byrd (hip), WR Ruvell Martin (ankle), G Chad Rinehart (calf)
Probable: TE Scott Chandler (head), WR Donald Jones (head)
Starting safety Eric Reid will not be available for the 49ers on Thursday night, and the other presumptive starting safeties are questionable, too.
Jimmie Ward (hamstring) and Jaquiski Tartt (neck) went through limited practice Wednesdsay and are listed as questionable to face the Los Angeles Rams in front of a national television audience at Levi’s Stadium on Thursday night.
Ward and Tartt are expected to be available for the game, but the 49ers’ only healthy safeties are rookies Lorenzo Jerome and Adrian Colbert.
Reid is expected miss more than one game with a sprain of the posterior cruciate ligament in his left knee. Reid is listed as out for Thursday’s game, along with linebacker Reuben Foster.
The 49ers medical staff no longer requires Foster to wear an orthopedic boot to stabilize his high right ankle sprain. General manager John Lynch said Foster is making good progress, but the 49ers are going to be cautious with him.
“The one thing I know is that freak athletes tend to be freak healers, as well,” Lynch told NBC Sports Bay Area.
“He wanted to play the first week in the boot. That’s just the way he’s wired. We got to make sure he’s all the way healthy before we put him in, and we’re going to do that.”
Tight end George Kittle (hip) and linebacker Eli Harold (foot) are questionable for the game and are expected to play. Kittle sustained his injury during the 49ers’ 12-9 loss to the Seattle Seahawks on Sunday. Harold was stepped on during a practice this week.
49ers injury report
LB Reuben Foster (ankle)
S Eric Reid (knee)
LB Eli Harold (foot)
TE George Kittle (hip)
S Jaquiski Tartt (neck)
S Jimmie Ward (hamstring)
The 49ers entered the regular season feeling as confident in quarterback Brian Hoyer as anyone on the offensive side of the ball.
But Hoyer has struggled through the worst back-to-back games of his 33-start NFL career. And the 49ers need him to get going, beginning Thursday night against the Los Angeles Rams, coach Kyle Shanahan said.
"I want him to get his edge back. I want him to get his confidence,” Shanahan said Wednesday on the KNBR Morning Show.
“We need Brian to step up, and we need everyone around him to step up.”
In the first two games of the season, Hoyer has completed 62.9 percent of his 62 pass attempts but for just 292 yards with no touchdowns and two interceptions. His passer rating is a lowly 60.7.
The 49ers have scored only four field goals and no touchdowns on their 21 offensive possessions in losses to Carolina and Seattle. Moreover, the 49ers have converted just four of 23 (17.4 percent) of their third-down attempts.
The quick turnaround on Thursday at Levi’s Stadium is something Hoyer said he welcomes this week -- of all weeks.
Last season with the Chicago Bears, Hoyer did not throw for fewer than 300 yards in any of his four full games. On Sunday in the 49ers’ 12-9 loss to the Seahawks, he managed just 99 yards passing.
“It was a tough game and now we move on,” Hoyer said. “Thankfully, this week we get to move on really quick and move on to LA.
”You get to put the last one behind you and move on to the next.”