In this mornings conference call, Buffalo head coach Chan Gailey told the Bay Area media that the 49ers have the best offensive line that his team will have faced at this point of the season. A few hours later, standing before the Bay Area media, Jim Harbaugh returned a similar compliment. This will be the best defensive line that weve played so far this year, Harbaugh said. Its a statement that might seem to defy reason as the Bills defense gave up 45 second half points in a 52-28 loss to the Patriots last Sunday and is one of the lower ranked units in the league.Some turnovers have gotten in their way, Harbaugh explained of the discrepancy. But if those were eliminated, they would be one of the most effective, explosive teams in the National Football League.There is no denying the size and talent among Buffalos front four. The Bills starting defensive line is responsible for eight of the teams 10 sacks. Defensive tackle Kyle Williams leads the bunch with 3.5. But the 49ers are getting familiar with all of them.Youll see the equivalent of Justin Smith on their side, extremely athletic on the edges, Harbaugh said, and an inside tackle that is maybe the most powerful, athletic tackle in the game. Marcell Dareus doesnt come out ever. Hes in there in the pass rush downs. A big 330 plus guy that can move. Its impressive when you watch the film, the endzone shot of him lined up, hes a big powerful man that can run. They are skilled talent.I think they are the best of the bunch. All four of those guys. All, very, very talented, left tackle Joe Staley said. I think the best player is Kyle Williams Very underrated player. Doesnt get the national press that the other guys do. Hes very solid, very impressive player. And then Mark Anderson on my side, very athletic, very speedy guy. Got a lot of moves. And Dareus as well, hes a monster. Very talented big guy. The thing about him too is he doesnt come off the field in third down situations. Hes a 335 pound guy. That speaks to his athleticism. You dont see that very often. Its a huge challenge in front of us.That challenge will be keeping the Bills' front defensive four away from Alex Smith, who for more than one reason, is one of the more sacked quarterbacks in the league. The 49ers will rely on their own strategy to keep that from happening and not necessarily what worked for New England. You learn from all the film, Alex Smith explained. The Patriots are different. All the teams are different. You learn from it here and there but its a different system they have different players so you take what you can.These teams are not familiar with each other as they have not played since 2008, so the 49ers realize they will have to be prepared to adjust to differences on the field compared to what they see on film. Safety Donte Whitner spent his first five seasons in the league with Buffalo before signing a three year deal with San Francisco last season. He says one thing he knows about his former team, after a loss like last weeks to the Patriots, the Bills will come to Candlestick and play as if their backs are against the wall.