The 49ers are the ninth most valuable franchise in the NFL, according to Forbes' latest valuations.
Last year, Jed York's team clocked in as the 10th most valuable at an estimated $1.224 billion.
This year, the club's owner could fetch an estimated $1.6 billion, an increase of $376 million.
After 33 seasons in Candlestick Park, the 49ers have a new home in Santa Clara.
The 68,500 seat Levi's Stadium will host Super Bowl 50 in February, 2016.
The franchise has a 20-year, $220 million naming rights deal with Levi Strauss, a reported 70% of which will be used to pay off stadium debt.
The 49ers also have more than $800 million in commitments for seat and luxury box sales.
The Seahawks are 15th on Forbes' list, valued at an estimated $1.33 billion.