Justin Smith inactive

Justin Smith inactive

SEATTLE -- Defensive tackle Justin Smith's ironman streak came to an end Sunday night.

Smith, who started 185 consecutive games since his rookie season of 2001, was declared inactive for the 49ers' game against the Seattle Seahawks due to a left elbow injury.

Smith sustained the undisclosed injury early in the second half of the 49ers' 41-34 victory over the New England Patriots. He was unable to return to action. Smith did not practice last week. The 49ers listed Smith as questionable on their official injury report.

Smith's availability for the final regular-season game next week against the Arizona Cardinals and for the playoffs is not known.

Defensive lineman Ricky Jean Francois will start in place of Smith on Sunday. It'll be the fourth start of Jean Francois' career.

Receiver Mario Manningham returns to the lineup after missing two games with a shoulder injury. Rookie A.J. Jenkins returns to the inactive list with Manningham returning to action. Rookie outside linebacker Cam Johnson will make his NFL debut with veteran Clark Haggans out with a shoulder injury. Johnson will wear No. 50.

For the Seahawks, rookie Jeremy Lane will start at right cornerback for Walter Thurmond, and J.R. Sweezy gets the start at right guard for John Moffitt.

49ers inactives
QB Scott Tolzien
WR A.J. Jenkins
S Trenton Robinson
RB Jewel Hampton
LB Clark Haggans
G Joe Looney
DT Justin Smith

Seahawks inactives
CB Marcus Trufant
CB Walter Thurmond
CB DeShawn Shead
G Rishaw Johnson
G John Moffitt
T Mike Person
DT Jaye Howard

Source: 49ers agree to four-year deal with former Dolphins DT

Source: 49ers agree to four-year deal with former Dolphins DT

The San Francisco 49ers agreed to a four-year, $16 million deal with defensive tackle Earl Mitchell on Friday, CSNBayArea.com has learned

Mitchell, 29, will earn $5.5 million in his first year with the 49ers. 

The seven-year veteran played in nine games last season for the Dolphins. He recorded 17 total tackles. 

Since entering the league in 2010 as a third-round draft pick with the Texans, Mitchell has appeared in 100 games between Houston and Miami, totaling 206 tackles. He has also recorded 5.5 sacks. 

49ers 2017 NFL Draft picks

49ers 2017 NFL Draft picks

The San Francisco 49ers have a total of 10 picks in the 2017 NFL Draft. 

Here is where they will be on the clock in each round:

1. First round: No. 2 overall
2. Second round: No. 34 overall
3. Third round: No. 66 overall
4. Fourth round: No. 109 overall
5. Fourth round: No. 143 overall (compensatory)
6. Fifth round: No. 146 overall
7. Fifth round: No. 161 (pick acquired from Washington in 2015 trade for TE Derek Carrier)
8. Sixth round: No. 186 overall
9. Sixth round: No. 202 overall (pick acquired from Denver in 2015 trade for TE Vernon Davis)
10. Seventh round: No. 219 overall (pick acquired from Cleveland in 2015 trade for Andy Lee)