NFL capsule: 49ers 12-point favorites vs. Rams

ST. LOUIS (3-5) At SAN FRANCISCO (6-2)Sunday, 4:25 p.m., FOXOPENING LINE - 49ers by 12RECORD VS. SPREAD - St. Louis 5-3; San Francisco 5-3SERIES RECORD - 49ers lead 62-61-2AP Pro32 RANKING - Rams No. 26; 49ers No. 4LAST MEETING - 49ers beat Rams 34-27, Jan. 1, 2012LAST WEEK - Rams had bye; 49ers had byeSTREAKS, STATS AND NOTES - Niners have won seven of last eight in series. ... Rams on three-game losing streak. ... San Francisco tries to move to 2-0 after bye week under coach Jim Harbaugh. ... 49ers beat Rams 26-0 last Dec. 4 at Candlestick Park to clinch franchise's first playoff berth since 2002. ... RB Frank Gore became 49ers' career rushing leader in that game by passing late Hall of Famer Joe Perry. ... 49ers have 11-game home winning streak against NFC West dating to Oct. 26, 2008, loss to Seahawks. ... St. Louis begins stretch with three of four vs. NFC West. It's team's first road matchup against division after beating Arizona and Seattle at home. ... San Francisco QB Alex Smith connected with nine receivers in 24-3 road rout of Cardinals on Monday night game of Oct. 29. Completed 18 of 19 passes for 232 yards, three TDs, and 157.1 passer rating. ... San Francisco defense held Arizona to 7 yards rushing on nine carries, tying franchise record for fewest yards rushing allowed in game. ... 49ers wideout Michael Crabtree has TD catch in each of last four games vs. Rams. ... Rams WR Danny Amendola has missed three straight games with right shoulder injury, including 45-7 loss to Patriots at London's Wembley Stadium on Oct. 28. Limited in practice this week. LT Wayne Hunter sat out last two games with back injury. ... Rams QB Sam Bradford threw for 205 yards and TD against Patriots, has passed for 1,797 yards and eight TDs this year. ... Rams LB James Laurinaitis and 49ers RT Alex Boone were roommates for year at Ohio State and both insist they plan to trash talk as much as possible.