YOUNGSTOWN, Ohio -- Running back Brandon Jacobs, out of the 49ers lineup since Aug. 18 with a left knee sprain, returned to limited practice Wednesday at Youngstown State.Jacobs wore full pads for the first time since sustaining his injury against the Houston Texans in the 49ers' second exhibition game. He took part in warmups, but not the full practice. His availability is questionable for Sunday's game against the New York Jets.The 49ers are spending this week practicing in Youngstown to adapt to the Eastern time zone for Sunday's game.Nose tackle Isaac Sopoaga, who sustained left knee and ankle sprains in the fourth quarter Sunday against the Minnesota Vikings, did not practice. Coach Jim Harbaugh said earlier this week that Sopoaga's X-ray checked out OK. But Sopoaga's knee appeared stiff as he was walking around the team hotel on Wednesday.Receiver Ted Ginn, who was limited in practice all last week, again took part in a limited practice schedule on Wednesday.Linebacker Patrick Willis, who sustained a mild right ankle sprain in the 49ers' loss to the Vikings, practiced and shows no ill-effects from his late-game injury.PARTICIPATION REPORTS49ers: NT Isaac Sopoaga (ankle, knee) did not practice; WR Ted Ginn (ankle), RB Brandon Jacobs (knee) were limited; LB Patrick Willis (ankle), P Andy Lee (hand) full practice.Jets: CB Darrelle Revis (knee) is out; WR Stephen Hill (hamstring), LB Bart Scott (toe), Eric Smith (hip, knee) did not practice; RB John Connor (knee), TE Dustin Keller (hamstring), LB Bryan Thomas (hamstring), WR Patrick Turner (hamstring) were limited; LB Nick Bellore (shoulder), CB Antonio Cromartie (shoulder), DT Mike Devito (calf), S LaRon Landry (heel), CB Ellis Lankster (back), C Nick Mangold (wrist), G Brandon Moore (hip), LB Calvin Pace (Achilles), DT Sione Pouhe (back), QB Mark Sanchez (back), CB Isaiah Trufant (ankle) full practice.