With their seventh straight win, the 49ers clinched a winning season for the first time since 2002 and could clinch the division next week if Jim Harbaugh can best his brother in Baltimore and Seattle loses to the Rams.
Both rookie fullback Bruce Miller and second-year tackle Anthony Davis sustained injuries in the 49ers' win over the Cardinals that could keep them from playing on Thanksgiving Day in Baltimore.
Safety Dashon Goldson was ejected in the fourth quarter from the 49ers' game Sunday against the Arizona Cardinals for retaliating against receiver Early Doucet with a flurry of punches.
After rushing for zero yards a week ago, Frank Gore is in the starting lineup and is expected to see a typical workload. Madieu Williams is inactive for the first time this season.
Will the 49ers handle Gore any different than usual Sunday against the Arizona Cardinals with another game looming just four days later at Baltimore on Thanksgiving night?
With San Francisco seeking an eighth straight victory on Sunday, our 49ers Insider takes the guess work out of the match-up with Arizona. What are the 49ers going to do to stop explosive Larry Fitzgerald? Glad you asked.
The 49ers' implementation of unique shifts is getting attention around the league, including an interesting description by the Cardinals' defensive coordinator, who will be responsible for dealing with them Sunday.
Starting cornerback Tarell Brown is questionable for Sunday's game against the Arizona Cardinals after he "bumped" his knee in practice Friday.
Yes, we reported Friday morning that Alex Smith bought chairs for the 49ers offensive line. But the Alex was actually Alex Boone, as Jaymee Sire discovered when she asked Boone about Smith's apparent generosity.
In Part II of Matt Maiocco's interview with 49ers offensive line coaches Mike Solari and Tim Drevno, lineman Anthony Davis is highlighted as a player maturing in all areas, including improvement in the weight room.
Matt Maiocco was fortunate enough to sit down with 49ers offensive line coaches Mike Solari and Tim Drevno. In Part 1 of the two-part interview, we learn how the two built their relationship during the lockout.
In the 49ers' first three games, Alex Smith was sacked 11 times. In their last six games, that number has shrunk to just 10. How has the 49ers' signal-caller rewarded the big men up front? One word -- comfort.
The 49ers offense is ranked 24th in red-zone efficiency, and center Jonathan Goodwin knows they can do better. "There's a lot we can clean up."
A few plays in the 49ers' big win over the Giants had the New York head coach prickly with the New York media this week. Jim Harbaugh can't, or refuses to understand why.
Frank Gore, who is recovering from a right knee bruise, did not take part in 49ers practice Wednesday, despite head coach Jim Harbaugh saying he believed his star running back would earlier in the day.