Alex Smith was sacked a season-high nine times and the 49ers were victims of two costly first-half penalties as Joe Flacco staged fourth-quarter drives to serve younger-brother Jim Harbaugh his first loss since Week 2.
The 49ers do not have to worry about Baltimore Ravens linebacker Ray Lewis on Thursday night.
Jim Harbaugh placed his trust in Alex Smith when previous coaches seemingly had been quick to lose confidence in the quarterback.
The crew on the NFL Network's "NFL GameDay Morning" talked Thursday about the tag of "game manager" as it applies to 49ers quarterback Alex Smith.
The 49ers' best defender and the Ravens' top producer will take center stage Thursday, and they are bound to see a lot of each other throughout the night. Ray Rice, meet Patrick Willis.
With the Ravens and 49ers playing in the much-ballyhooed meeting of the Brothers Harbaugh, CSNBaltimore.com and CSNBayArea.com's Insiders give their take.
Offensive coordinator Greg Roman said the 49ers drew up a few plays on the fly in their win over the Cardinals. Those improvisational skills might come in handy again on Thanksgiving.
There are a lot of comparisons to be made between Ravens veteran Ray Lewis and the 49ers' Patrick Willis. But one comparison that had not been made prior to this season is in the area of motivational speaking.
Mike Mayock, who will serve as the NFL Network analyst for the 49ers' Thanksgiving night game against the Ravens, says Alex Smith has earned the right to be the 49ers' QB for the foreseeable future.
49ers defensive coordinator Vic Fangio has worked for both Jim and John Harbaugh, and he'll tell you a little bit about each guy, but as for the differences in their coaching? "That's top secret."
Fullback Bruce Miller was an onlooker during the warmup period of 49ers practice late Tuesday afternoon, two days after sustaining a concussion. His availability for Thursday's game against the Ravens remains unclear.
Former 49ers owner Eddie DeBartolo, a five-time Super Bowl champion, is among 26 semifinalists announced Tuesday for the Class of 2012 Pro Football Hall of Fame.
The 49ers defense forced the Cardinals into five turnovers and allowed just 229 total yards. Patrick Willis registered seven tackles, an interception, and a forced fumble.
Right tackle Anthony Davis says he's recovering fine from his right ankle sprain which he suffered on Sunday, and he proved it to reporters in the locker room on Tuesday.
Safety Dashon Goldson will not be suspended for fighting Sunday with Arizona Cardinals receiver Early Doucet, an NFL spokesman told CSNBayArea.com.