Isaac Sopoaga's recent staph infection comes on the heels of three previous infections incurred by Joshua Morgan, Keith Lewis and and Ricky Jean Francois.
Nose tackle Isaac Sopoaga, who also made a major contribution on the 49ers' offense the past two weeks as a blocking back, did not practice Wednesday due to an infection.
When Alex Smith was cleaning out his locker in January, he was wearing a San Diego Padres hat. So what's behind the switch to the Giants lid?
The 49ers worked out free-agent running backs Dimitri Nance, Jalen Permele and Tyrell Sutton on Tuesday, a league source told CSNBayArea.com.
The 49ers' defense may have given up a lot of yards against the Eagles, but they kept Philly out of the endzone in the second half, keeping the door ajar for their big comeback.
Alex Smith started slowly, but his second half was spectacular. Insider Matt Maiocco goes up and down the offensive roster with a fine tooth comb to look at the players who engineered an unlikely win in Philadelphia.
The 49ers won a rare road game Sunday that wasn't exactly an aesthetic masterpiece. But a win is a win. And they did it with their supporting cast playing a significant role.
Jim Harbaugh said he was prepared to dispute whether Michael Crabtree stepped out of bounds in the third quarter. But the telecast never showed a replay until it was too late.
The 49ers' offense looked lost through two plus quarters, but Alex Smith, Vernon Davis, and Kendall Hunter spearheaded a comeback that lifted the 49ers to 2-1 and alone in first place in the NFC West.
Jim Harbaugh has all the confidence in the world in David Akers. Why shouldn't he? Akers is a perfect seven-for-seven in FG attempt in 2011.
After only catching two passes last week against Dallas, Vernon Davis expressed surprise at how little he was deployed. After speaking about it with Coach Harbaugh, Davis made his presence felt against the Bengals.
We are just over an hour away from kickoff which means it's time to list the inactive players for both the 49ers and Bengals. Will the 49ers miss Braylon Edwards, or will Michael Crabtree fill the void in a big way?
On Tuesday, a package containing 2 12 pounds of marijuana -- shipped from Eureka, Humboldt County -- was tracked to Simpson's home in northern Kentucky, authorities said. However, he is expected to play.
No. 15 isn't likely to start but will be worked into the offensive mix in third-down situations. Beyond that, only Jim Harbaugh knows.