UPDATE (Nov. 22, 3 p.m.) -- Bovada.lv has updated their line, making the 49ers 1-point favorites over the Seahawks.
SAN FRANCISCO (10-3-1) At SEATTLE (9-5)
Sunday, 8:20 p.m., NBC
OPENING LINE - Seahawks by 2.5
RECORD VS. SPREAD - San Francisco 9-5; Seattle 10-4
SERIES RECORD - 49ers lead 14-13
AP PRO32 RANKING - 49ers No. 2; Seahawks No. 7
LAST MEETING - 49ers beat Seahawks 13-6, Oct. 18
LAST WEEK - 49ers beat Patriots 41-34; Seahawks beat Bills 50-17
STREAKS, STATS AND NOTES - Game flexed into prime time by NFL. Will be sixth prime-time game this season for 49ers and second for Seahawks. ... 49ers clinch second straight NFC West title with win. They have not won consecutive division titles since 1994 and '95. ... Seahawks clinch at least wild-card berth with victory and keep alive hopes of division title. ... 49ers have won last four in series, including 13-6 in October in San Francisco. ... 49ers coach Jim Harbaugh 3-0 against Seattle coach Pete Carroll in NFL. ... QB Colin Kaepernick's four TD passes last week vs. New England was career-high and most for any San Francisco QB since 2003. ... Since becoming starter, Kaepernick 4-1 with seven TD passes, two interceptions and QB rating of 104.4. ... RB Frank Gore has not reached 100-yard mark since victory over Seattle when he had 131 yards. ... WR Michael Crabtree has 23 receptions for 301 yards past three games. ... TE Vernon Davis held without catch in first game vs. Seattle. Was first time since 2008 Davis went without reception. ... 49ers lead NFL in scoring defense giving up 15.57 points per game. Seahawks No. 2 at 15.64. ... DE Justin Smith has left elbow injury suffered against New England. Harbaugh believes he'll play. Smith has streak of 185 consecutive starts. ... LB Aldon Smith tied for NFL lead with 19 1/2 sacks, three shy of NFL record. Smith held without sack last week vs. New England for first time since Week 6. Smith's 29 sacks in first two seasons third most in NFL history behind Reggie White and Derrick Thomas. .... Seahawks coming off consecutive outbursts of 50 or more points (58-0 vs. Arizona and 50-17 at Buffalo), becoming first team since 1950 to reach half-century mark in consecutive games. ... Seahawks QB Russell Wilson rushed for three touchdowns and franchise-record 92 yards in win over Buffalo. ... Win on Sunday would give Wilson seven home wins as rookie starter, matching Ben Roethlisberger for most home victories by rookie QB. ... RB Marshawn Lynch has 241 yards rushing on 21 carries past two games. ... Lynch second in NFL in yards rushing with 1,379. ... Seattle's offense ranked 30th in league after losing to 49ers in Week 7. Has risen to 16th this week.