The Giants begin their interleague series with the Blue Jays missing two key bats vs. last season's AL East champions Monday night.
Managers Bruce Bochy and John Gibbons have issued their lineup cards for the first of a three-game series.
Toronto Blue Jays (16-17)
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1. Kevin Pillar (R) CF
2. Josh Donaldson (R) 3B
3. Jose Bautista (R) RF
4. Edwin Encarnacion (R) 1B
5. Michael Saunders (L) LF
6. Troy Tulowitzki (R) SS
7. Russell Martin (R) C
8. Ryan Goins (L) 2B
9. Aaron Sanchez (R) P
San Francisco Giants (17-16)
1. Denard Span (L) CF
2. Joe Panik (L) 2B
3. Matt Duffy (R) 3B
4. Brandon Belt (L) 1B
5. Hunter Pence (R) RF
6. Brandon Crawford (L) SS
7. Gregor Blanco (L) LF
8. Trevor Brown (R) C
9. Jake Peavy (R) P