Adam Snyder

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SANTA CLARA -- Guard Mike Iupati did not practice Wednesday due to a left knee injury, as the 49ers began their week of work to get prepared to face the unbeaten Detroit Lions on Sunday.Iupati'

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After watching the Detroit Lions remain unbeaten Monday night with a 24-13 victory over the Chicago Bears, here are some of my initial thoughts about the upcoming game against the 49ers (4-1):-- Ad

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SANTA CLARA -- Nose tackle Isaac Sopoaga, who missed Sunday's game due to a staph infection, was spotted leaving the 49ers' practice facility Monday morning with his left arm in a sling.T

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For the first time in his career, quarterback Alex Smith was removed from a game because of success.

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SAN FRANCISCO -- In a hallway at the Holiday Inn in Boardman, Ohio, 49ers left tackle Joe Staley supplied a quote that was bound to be revisited throughout the season."Contrary to what everybo

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