The next Biggest Game of the Year is coming up Sunday in Seattle. Let's open the 49ers Mailbag to see what's on the minds of readers . . .
SANTA CLARA -- All-Pro defensive tackle Justin Smith was not on the 49ers' field at the beginning of practice Thursday, casting serious doubt whether he will be available Sunday night to face the
SANTA CLARA -- Mario Manningham, who has missed the past two games with a shoulder injury and did not travel to New England, took part in limited practice on Wednesday.
SANTA CLARA -- All-Pro defensive tackle Justin Smith, who sat out most of the second half of Sunday night's game against the New England Patriots with an unspecified injury to his left elbow, was