Justin Smith

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SEATTLE -- The San Francisco 49ers will be without defensive tackle Justin Smith because

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SANTA CLARA -- All-Pro defensive tackle Justin Smith's amazing streak of durability is in jeopardy.

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The next Biggest Game of the Year is coming up Sunday in Seattle. Let's open the 49ers Mailbag to see what's on the minds of readers . . .

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SANTA CLARA -- All-Pro defensive tackle Justin Smith was not on the 49ers' field at the beginning of practice Thursday, casting serious doubt whether he will be available Sunday night to face the

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SANTA CLARA -- Mario Manningham, who has missed the past two games with a shoulder injury and did not travel to New England, took part in limited practice on Wednesday.

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