Matt Maiocco

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SAN FRANCISCO – The 49ers are hopeful left tackle Joe Staley will return after a week or two on the sideline.

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SAN FRANCISCO -- Pro Bowl left tackle Joe Staley sustained a right knee injury on the 49ers' first offensive possession and will not return to action Sunday against the St. Louis Rams.

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SAN FRANCISCO – Wide receiver Michael Crabtree is set to make his season debut on Sunday, as he will be in uniform for the first time this season.

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Editor's note: This is the final part in a series that spotlights three 49ers-Rams matchups to watch Sunday, 1:05 p.m., at Candlestick Park

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