Mike Iupati

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Pro Bowl guard Mike Iupati sustained a sprained left medial collateral ligament in his left knee and is expected to miss some playing time, a source told CSNBayArea.com on Monday.

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NEW ORLEANS -- The 49ers lost two starters to injuries that could have an impact in future weeks.

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Editor's note: This is the first part in a series that spotlights three 49ers-Panthers matchups to watch Sunday, 1:05 p.m., at Candlestick Park.

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