SAN FRANCISCO -- Nose tackle Isaac Sopoaga is inactive for the 49ers' game Sunday against the Tampa Bay Buccaneers due to a staph infection that kept him out of practice last week.Ricky Jean Francois will start at nose tackle. Undrafted rookie defensive linemen Demarcus Dobbs and Ian Williams will suit up for the first time this season.Cornerback Shawntae Spencer and safety Donte Whitner are active for the game. Spencer was hobbled with a toe injury last week during practice. Whitner has not played since sustaining a left hip contusion on the opening drive two weeks ago against the Cincinnati Bengals.Rookie fullback Bruce Miller will get his third start in place of Moran Norris, who sustained a fractured left fibula Sept. 18 against the Dallas Cowboys. Norris is expected to miss six to eight weeks.Receiver Braylon Edwards, who underwent arthroscopic surgery to repair torn cartilage in his right knee three weeks ago, is expected to return to action Oct. 30 against Cleveland.Running back Frank Gore will return to the starting lineup for the 49ers. Kendall Hunter started last week's game, as Gore's practice time was limited with an ankle sprain.For the Buccaneers, Dekoda Watson starts at strongside linebacker in place of Quincy Black, who is inactive with an ankle sprain.49ers inactive players: Quarterback Scott Tolzien, cornerback Tramaine Brock (left hand), receiver Braylon Edwards (right knee), fullback Moran Norris (left fibula), guard Daniel Kilgore, tackle Mike Person and nose tackle Isaac Sopoaga (staph infection).Buccaneers inactive players: Receiver Sammie Stroughter (foot), safety Devin Holland (back), linebacker Zac Diles (hamstring), linebacker Quincy Black (ankle), tackle Derek Hardman, tackle James Lee (knee) and tight end Luke Stocker (knee).