With Andre Iguodala joining David Lee and Andrew Bogut on the sideline Wednesday night, the Warriors took a beating at the AT&T Center in San Antonio.
The 111-90 whacking by the Spurs was the Warriors' 31st consecutive regular season loss in San Antonio and gave Gregg Popovich's team a four-game sweep of the Warriors this season.
San Antonio extended to 19 its franchise-record win streak, while the Warriors (46-29) return to Oakland with a split of the two-game, two-night road trip.
Having beaten Dallas in overtime one night earlier, the Warriors entered the arena as prohibitive underdogs. Coach Mark Jackson decided to rest Iguodala, who played 41 highly effective minutes against the Mavericks but continues to battle the knee tendinitis that kept him out of three games late last month.
With frontcourt Lee and Bogut already declared out, the Warriors started a lineup featuring Harrison Barnes, Draymond Green, Jermaine O'Neal, Klay Thompson and Stephen Curry.
O'Neal played only four minutes, leaving in the first quarter and not returning.
Marreese Speights led four Warriors in double figures with 22 points. Jordan Crawford finished with 16, Thompson with 15 and Curry with 11.
The Warriors were outrebounded 45-33 and outshot 53 percent to 42.4 percent.
Point guard Tony Parker led the Spurs (59-16) with 18 points in 29 minutes. Five other Spurs scored in double figures, including Tim Duncan (15), Patty Mills (13) and Manu Ginobili (13).
STANDOUT PERFORMER: Speights came off the bench to score 22 points on 10-of-16 shooting and grab eight rebounds.
TURNING POINT: When the Warriors took a 4-0 lead 69 seconds into the game, San Antonio coach Gregg Popovich called a timeout. The Spurs responded by taking command, rolling to a 29-8 run that forged a 29-12 lead with 2:17 in the quarter.
The Warriors spent the rest of the game playing catch-up and never did, getting no closer than seven (74-67, 4:30 left in the third quarter) over the final 38 minutes.
INJURY UPDATE: SF Andre Iguodala (right knee tendinitis) and PF David Lee (strained right hamstring) are with the team but did not play. C Andrew Bogut (pelvis/groin contusion) is not with the team. C Festus Ezeli (right knee surgery rehab) is with the team but remains out indefinitely.
WHAT'S NEXT: The Warriors on Thursday return to the Bay Area, where on Friday they face the Sacramento Kings at Oracle Arena. The Warriors, having won all three previous meetings this season, are seeking a four-game series sweep.